Educational Articles
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Phenoxybenzamine is given by mouth and is used off label to treat urination difficulty related to sphincter tone, high blood pressure related to pheochromocytoma, and laminitis in horses. Phenoxybenzamine should be given as directed by your veterinarian. Common side effects include nausea, vomiting, diarrhea, small pupils, increased heart rate, and nasal congestion/stuffy nose. Do not use in pets that are allergic to it, in pets that cannot handle low blood pressure, or in horses with colic. If a negative reaction occurs, please call your veterinary office.
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Phenylbutazone (brand names: Butazolidin, VetriBute, Butatron, Phenylbute) is given by mouth in the form of a paste, powder, tablet, or granules or by an injection into the vein in horses. Do not use this medication in horses that are allergic to it. If a negative reaction occurs, please call your veterinary office.
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Polysulfated glycosaminoglycan is an injectable disease-modifying osteoarthritis drug (DMOAD) used to treat non-infectious and traumatic arthritis in dogs. It is also used off-label in cats and small mammals. If administering this medication at home, follow your veterinarian’s instructions and dispose of the needle and syringe appropriately. Side effects are rare when given according to label recommendations and at prescribed intervals. Do not use this medication in pets with a known hypersensitivity to it, in pets with known or suspected bleeding disorders or immune-mediated arthritis, or in pets with severe kidney or liver disorders.
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Praziquantel is given on and off label and by mouth or injection to treat various internal parasites in cats, dogs, small mammals, birds, reptiles, and large animals. Do not use in pets that are allergic to it, in puppies less than 3 weeks old, or kittens less than 6 weeks old.
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Prednisone/prednisolone is given by mouth or injection and is used on and off label to treat Addison’s disease, inflammatory conditions, neoplasia (cancer), and immune-mediated diseases. Give this medication as directed by your veterinarian. Common side effects include increased drinking, increased urination, and increased appetite. Do not use in pets that are allergic to it, or pets with systemic fungal infections, viral infections, ulcers, tuberculosis, or Cushing’s disease. If a negative reaction occurs, please call your veterinary office.
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Probiotics are given by mouth and are used over the counter to treat gastrointestinal upset. Give as directed by your veterinarian. Side effects are rare but may include gas or mild discomfort. Do not use in pets that are very sick and immunocompromised, or in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.
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Procainamide (brand names Pronestyl®, Biocoryl®, Procan®, Procanbid®) is an antiarrhythmic drug used off label (extra label) in dogs and horses to treat abnormal heart rhythms such as atrial fibrillation, ventricular premature complexes, and ventricular tachycardia.
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Propantheline bromide is given by mouth or injection and is used off label to treat diarrhea, slow heart rate, and incontinence. Give as directed by your veterinarian. Common side effects include dry mouth, dry eyes, fast heart rate, difficulty urinating, and constipation. Do not use in pets that are allergic to it or similar drugs, or pets that have certain heart, bladder, or intestinal problems, glaucoma, or myasthenia gravis. If a negative reaction occurs, please call your veterinary office.
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Propranolol (brand names Inderal®, Detensol®, Hemangeol®, Innopran®) is a beta-blocker used off label (extra label) to treat abnormal heart rhythms (arrhythmias) in cats, dogs, ferrets, and horses. It has also been used short-term to treat hypertension caused by thyrotoxicosis or pheochromocytoma. It is given by mouth or injection.
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Rifampin is commonly used off label to treat infections in horses, and occasionally in dogs and cats. It is usually given by mouth in the form of a capsule or compounded liquid. The most common side effects are vomiting, diarrhea, or reduced appetite. Liver dysfunction is possible. A change in the color of urine, tears, and saliva to a red/orange color is expected but may stain fabrics. Use with caution in pets that have pre-existing liver disease, are pregnant, are elderly, or are lactating. If a negative reaction occurs, call your veterinary office.
